Page 188 - Hospital Authority Convention 2017
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Parallel Sessions                                                      Parallel Sessions
      HOSPITAL AUTHORITY CONVENTION 2017


             PS8.1     Technology Advancement and Innovation                10:45  Room 423 & Room 424

            Advancement in Rehabilitating Spinal Movement Control with 3D Motion Analysis
                  1
            Chun E , Tsang S  2
            1                                         2
             Physiotherapy Department, Prince of Wales Hospital,  Department of Rehabilitation Sciences, The Hong Kong Polytechnic
            University, Hong Kong
            Low back pain (LBP) is a highly prevalent musculoskeletal dysfunction which contributes to substantial demand on medical
            care and rehabilitation globally. LBP sufferers frequently encounter difficulty in functional activities involving forward bending
            movement possibly due to pain, stiffness and inadequate flexibility. Previous research suggested that repeated bending
            remains one of the major factors contributing to the development and chronicity of LBP. People with LBP were found to have
            significantly lower speed of moving the lumbar spine during forward bending. Deficits of kinematics and interplay between
            the lumbo-pelvic region could be more profound if the bending task is performed at paces other than comfortable or self-
            preferred level. To better understand the possible strategies to enhance the outcome of prevention and rehabilitation of LBP,
            analysis of lumbo-pelvic movements during forward bending using the three-dimensional (3D) motion capturing system (Vicon)
            was carried out in a group of patients suffered from LBP. The effects of a wide range of bending speeds on the dynamic
            movement coordination, motor and balance control of  the lumbar spine and  hip joint during forward bending in standing
            were examined. The findings contribute to the understanding of adaptive changes of the movement, motor control of the
            lumbo-pelvic region and balance strategies adopted by individuals with chronic LBP while executing this simple but usually
            symptom-provocative task.

            The experience of application of 3D motion analysis in evaluating the recovery of individuals with LBP at Prince of Wales
            Hospital will be shared. The outcomes of lumbo-pelvic movement control and patterns in terms of kinematics and kinetics,
            before and after a structured rehabilitation programme which emphasised on abdominal core strengthening and motor
            control exercises will also be discussed.












             PS8.2     Technology Advancement and Innovation                10:45  Room 423 & Room 424

            Advanced Diagnostic Technology and Laboratory Operations – Next Generation Sequencing in Pathology and
            Genetics Testing
            Wong W
            Hong Kong Children’s Hospital Commissioning Team, Strategy and Service Planning Division, Hospital Authority Head Office,
            Hong Kong
      Wednesday, 17 May  highly complex and diverse group of diseases, including inherited diseases and cancers. Based on the high sensitivity and
            The rapid development of next generation sequencing (NGS) technologies has driven a revolution in laboratories to investigate
            throughput, NGS does not only extend the amount of genetic information but also largely reduce the sequencing costs
            through innovations in chemistry, optics, fluidics, computational hardware, and bioinformatics solutions. These features make
            NGS an effective and promising tool in clinical applications. A significant number of tumour markers and somatic variants
            have been discovered, making improved diagnostic and treatment decisions.

            Different NGS platforms have different capabilities in detection of DNA or RNA sequence variations, genomic expression,
            DNA copy number variations and rearrangements, etc. A single method usually provides only part of this variety of
            information, while the cost, specimen type, and application considerations are very important. Advantage of NGS is that
            it uses just one sample in one workflow to test mutation status across multiple genes. However, there are still technical,
            analytical and ethics issues that need further refinement because the abilities of accurate calling the functional variants
            and comprehensive understanding of disease producing genetic variants are still limited. Although long-read sequencing
            overcomes the length limitation of other NGS approaches, it remains considerably expensive.

            Generation of this vast amount of data brings challenges for both analysis and infrastructure, requiring innovative storage and
            bioinformatics solutions from the laboratories. Reliable algorithms have to be developed by clinical bioinformatics scientists
            and pathologists specially trained for complicated sequencing data analysis. Validation of the workflow and the pipeline of
            NGS application are demanding. A lack of reference materials for validation, proficiency testing and databases curated to
            accept clinical standards are likely the most significant challenge in managing and reporting genome sequencing data. This
            presentation is an overview of the features and the workflow of NGS application and examples of clinical applications of NGS
            in studying cancers.





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