Page 188 - Hospital Authority Convention 2017

Parallel Sessions Parallel Sessions
HOSPITAL AUTHORITY CONVENTION 2017

PS8.1 Technology Advancement and Innovation 10:45 Room 423 & Room 424

Advancement in Rehabilitating Spinal Movement Control with 3D Motion Analysis
1
Chun E , Tsang S 2
1 2
Physiotherapy Department, Prince of Wales Hospital, Department of Rehabilitation Sciences, The Hong Kong Polytechnic
University, Hong Kong
Low back pain (LBP) is a highly prevalent musculoskeletal dysfunction which contributes to substantial demand on medical
care and rehabilitation globally. LBP sufferers frequently encounter difficulty in functional activities involving forward bending
movement possibly due to pain, stiffness and inadequate flexibility. Previous research suggested that repeated bending
remains one of the major factors contributing to the development and chronicity of LBP. People with LBP were found to have
significantly lower speed of moving the lumbar spine during forward bending. Deficits of kinematics and interplay between
the lumbo-pelvic region could be more profound if the bending task is performed at paces other than comfortable or self-
preferred level. To better understand the possible strategies to enhance the outcome of prevention and rehabilitation of LBP,
analysis of lumbo-pelvic movements during forward bending using the three-dimensional (3D) motion capturing system (Vicon)
was carried out in a group of patients suffered from LBP. The effects of a wide range of bending speeds on the dynamic
movement coordination, motor and balance control of the lumbar spine and hip joint during forward bending in standing
were examined. The findings contribute to the understanding of adaptive changes of the movement, motor control of the
lumbo-pelvic region and balance strategies adopted by individuals with chronic LBP while executing this simple but usually
symptom-provocative task.

The experience of application of 3D motion analysis in evaluating the recovery of individuals with LBP at Prince of Wales
Hospital will be shared. The outcomes of lumbo-pelvic movement control and patterns in terms of kinematics and kinetics,
before and after a structured rehabilitation programme which emphasised on abdominal core strengthening and motor
control exercises will also be discussed.

PS8.2 Technology Advancement and Innovation 10:45 Room 423 & Room 424

Advanced Diagnostic Technology and Laboratory Operations – Next Generation Sequencing in Pathology and
Genetics Testing
Wong W
Hong Kong Children’s Hospital Commissioning Team, Strategy and Service Planning Division, Hospital Authority Head Office,
Hong Kong
Wednesday, 17 May highly complex and diverse group of diseases, including inherited diseases and cancers. Based on the high sensitivity and
The rapid development of next generation sequencing (NGS) technologies has driven a revolution in laboratories to investigate
throughput, NGS does not only extend the amount of genetic information but also largely reduce the sequencing costs
through innovations in chemistry, optics, fluidics, computational hardware, and bioinformatics solutions. These features make
NGS an effective and promising tool in clinical applications. A significant number of tumour markers and somatic variants
have been discovered, making improved diagnostic and treatment decisions.

Different NGS platforms have different capabilities in detection of DNA or RNA sequence variations, genomic expression,
DNA copy number variations and rearrangements, etc. A single method usually provides only part of this variety of
information, while the cost, specimen type, and application considerations are very important. Advantage of NGS is that
it uses just one sample in one workflow to test mutation status across multiple genes. However, there are still technical,
analytical and ethics issues that need further refinement because the abilities of accurate calling the functional variants
and comprehensive understanding of disease producing genetic variants are still limited. Although long-read sequencing
overcomes the length limitation of other NGS approaches, it remains considerably expensive.

Generation of this vast amount of data brings challenges for both analysis and infrastructure, requiring innovative storage and
bioinformatics solutions from the laboratories. Reliable algorithms have to be developed by clinical bioinformatics scientists
and pathologists specially trained for complicated sequencing data analysis. Validation of the workflow and the pipeline of
NGS application are demanding. A lack of reference materials for validation, proficiency testing and databases curated to
accept clinical standards are likely the most significant challenge in managing and reporting genome sequencing data. This
presentation is an overview of the features and the workflow of NGS application and examples of clinical applications of NGS
in studying cancers.

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