Highlights of accomplishments

• Organises regular workshops. These workshops are conducted by experienced researchers, aiming at promoting evidence-based practice in mental health, enhancing participants’ knowledge and improving their skills in carrying out a research.
• Develops the database of research conducted / conducting by colleagues of psychiatric service of New Territories West Cluster (NTWC) and uploads the database to the intranet of CPH
• Coordinates the SPSS web-base access stations in CPH
• Sets up the “Research Information Centre” at Block S, CPH
• Sets up the “Research Collection Corner” in the CPH Library
• Acts as a “clearing house” to assist Hospital Chief Executive to scrutinise the applications of all clinical and drug trials in the psychiatric units of NTWC, and standardise the application and implementation procedures
• Assists designing questionnaires inquiring the provisions of community residential care for psychiatric patients

Selected Publications

Clinical Psychiatry Research

• Hui, C. L. M., Wong, A. K. H., Ho, E. C. N., Lam, B. S. T., Hui, P. W. M., Tao, T. J., Chang, W. C., Chan, S. K. W., Lee, E. H. M., Suen, Y. N., Lam, M. M. L., Chiu, C. P. Y., Li, F. W. S., Leung, K. F., McGhee, S. M., Law, C. W., Chung, D. W. S., Yeung, W. S., Yiu, M. G. C., Pang, E. P. F., … Chen, E. Y. H. (2023). Effectiveness and optimal duration of early intervention treatment in adult-onset psychosis: a randomized clinical trial. Psychological medicine, 53(6), 2339–2351.
• Chan, R. Y. T., Hu, H. X., Wang, L. L., Chan, M. K. M., Ho, Z. T. Y., Cheng, K. M., Lui, S. S. Y., & Chan, R. C. K. (2023). Emotional subtypes in patients with depression: A cluster analysis. PsyCh journal, 12(3), 452–460.
• Tam, M. H. W., Ling-Ling, W., Cheng, K. M., Wong, J. O. Y., Cheung, E. F. C., Lui, S. S. Y., & Chan, R. C. K. (2021). Latent structure of self-report negative symptoms in patients with schizophrenia: A preliminary study. Asian journal of psychiatry, 61, 102680.
• Xie, D. J., Shi, H. S., Lui, S. S. Y., Shi, C., Li, Y., Ho, K. K. Y., et al. (2018). Cross Cultural validation and extension of the Clinical Assessment Interview for Negative Symptoms (CAINS) in the Chinese context: Evidence from a spectrum perspective. Schizophrenia Bulletin, 44(2), 547-555.
• Hui, C. L. M., Honer, W. G., Lee, E. H. M., Chang, W. C., Chan, S. K. W., Chen, E. S. M., et al. (2018). Long-term effects of discontinuation from antipsychotic maintenance following first-episode schizophrenia and related disorders: A 10 year follow-up of a randomised, double-blind trial. The Lancet Psychiatry, 5, 432-442.
• Cheng, K. M., Siu, B. W. M., Au Yeung, C. C. Y., Chiang, T. P., So, M. H., & Yeung, M. C. W. (2018). Telepsychiatry for stable Chinese psychiatric out-patients in custody in Hong Kong: A case-control pilot study. Hong Kong Medical Journal, 24, 378-383.
• Wong, S. Y., Zhang, D. X., Li, C. C. K., Yip, B. H. K., Chan, D. C. C., Ling, Y. M., et al. (2017). Comparing the effects of mindfulness-based cognitive therapy and sleep psycho-education with exercise on chronic insomnia: A randomised controlled trial. Psychotherapy and Psychosomatics, 86, 241-253.
• Chang, W. C., Wong, C. S. M., Chen, E. Y. H., Lam, L. C. W., Chan, W. C., Ng, R. M. K., et al. (2017). Lifetime prevalence and correlates of schizophrenia-spectrum, affective and other non-affective psychotic disorders in the Chinese adult population. Schizophrenia Bulletin, 43, 1280-1290.

Endophenotype Research

• Lui, S. S. Y., Wang, L. L., Lau, W. Y. S., Shing, E., Yeung, H. K. H., Tsang, K. C. M., Zhan, E. N., Cheung, E. S. L., Ho, K. K. Y., Hung, K. S. Y., Cheung, E. F. C., & Chan, R. C. K. (2023). Emotion-behaviour decoupling and experiential pleasure deficits predict negative symptoms and functional outcome in first-episode schizophrenia patients. Asian journal of psychiatry, 81, 103467.
• Zhou, H. Y., Lai, I. Y. S., Hung, K. S. Y., Chan, M. K. M., Ho, Z. T. Y., Lam, J. P. H., Lui, S. S. Y., & Chan, R. C. K. (2022). Audiovisual temporal processing in adult patients with first-episode schizophrenia and high-functioning autism. Schizophrenia (Heidelberg, Germany), 8(1), 75.
• Lui, S. S. Y., Zhang, R. T., Lau, W. Y. S., Liu, A. C. Y., Chui, W. W. H., Wang, Y., Tsang, K. C. M., Yeung, H. K. H., Cheung, E. F. C., & Chan, R. C. K. (2022). Prospective Memory Influences Social Functioning in People With First-Episode Schizophrenia: A Network Analysis and Longitudinal Study. The Journal of clinical psychiatry, 83(2), 21m14114.
• Li, S. B., Liu, C., Zhang, J. B., Wang, L. L., Hu, H. X., Chu, M. Y., Wang, Y., Lv, Q. Y., Lui, S. S. Y., Cheung, E. F. C., Yi, Z. H., & Chan, R. C. K. (2022). Revisiting the latent structure of negative symptoms in schizophrenia: Evidence from two second-generation clinical assessments. Schizophrenia research, 248, 131–139.
• Lui, S.S., Yip, S.S., Wang, Y., Hung, K.S., Ho, K.K., Tsang, K.C., Yeung, H.K., Cheung, E.F., & Chan, R.C. (2021). Different trajectories of neurological soft signs progression between treatment-responsive and treatment-resistant schizophrenia patients. Journal of psychiatric research, 138, 607-614.
• Lui, S. S. Y., Hung, K. S. Y., Wang, Y., Ho, K. K. Y., Yeung, H. K. H., Wang, Y., et al. (2018). Clustering of schizotypal features in unaffected first-degree relatives of schizophrenia patients. Schizophrenia Bulletin, 44(2), 536-546.
• Tin, L. N. W., Lui, S. S. Y., Ho, K. K. Y., Hung, K. S. Y., Wang, Y., Yeung, H. K. H., et al. (2018). High-functioning autism patients share similar but more severe impairments in verbal theory of mind than schizophrenia. Psychological Medicine, 48, 1264-1273.
• Chan, R. C. K., Xie, W., Geng, F. L., Wang, Y., Lui, S. S. Y., Wang, C. Y., Yu, X., et al. (2016). Clinical utility and lifespan profiling of neurological soft signs in schizophrenia spectrum disorders. Schizophrenia Bulletin, 42, 560-570.
• Lui, S. S. Y., Liu, A. C. Y., Chui, W. W. H., Li, Z., Geng, F., Wang, Y., et al. (2016). The nature of anhedonia and avolition in patients with first-episode schizophrenia. Psychological Medicine, 46, 437-447.
• Chan, R. C. K., Lui, S. S. Y., Wang, Y., Liu, A. C. Y., Chui, W. W. H., Shum, D. H. K., et al. (2013). Patients with bipolar disorders share similar but attenuated prospective memory impairments with patients with schizophrenia. Psychological Medicine, 43, 1639-1649.

Genetics Research

• Zhong, Y., Tubbs, J. D., Leung, P. B. M., Zhan, N., Hui, T. C. K., Ho, K. K. Y., Hung, K. S. Y., Cheung, E. F. C., So, H. C., Lui, S. S. Y., & Sham, P. C. (2024). Whole-exome sequencing in a Chinese sample provides preliminary evidence for the link between rare/low-frequency immune-related variants and early-onset schizophrenia. Asian journal of psychiatry, 96, 104046.
• Loh, P. R., Bhatia, G., Gusev, A., Finucane, H. K., Bulik-Sullivan, B. K., Pollack, S. J., et al. (2015). Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis. Nature Genetics, 47, 1385-1392.
• Schizophrenia Working Group of the Psychiatric Genomics Consortium. (2014). Biological insights from 108 schizophrenia-associated genetic loci. Nature, 511, 421-427.
• Wong, E. H. M., So, H. C., Li, M., Wang, Q., Butler, A. W., Paul, B., et al. (2014). Common variants on Xq28 conferring risk of schizophrenia in Han Chinese. Schizophrenia Bulletin, 40, 777-786.

Recovery-related Research

• Wong, R. H. K., Wing Cheong Au, R., Wai Lan, C., Pi Fan, C., Chiu, F. P. F., Chu, M. M. K., Chung Lung Kong, T., Lo, A. W. Y., Mak, D. C. S., Wong, J. K., & Yam, S. Y. (2023). A randomized controlled trial on the effectiveness of the abridged illness management and recovery program for people with schizophrenia spectrum disorders. Hong Kong journal of occupational therapy: HKJOT, 36(2), 118–127.
• Lau, S. W., Law, C. K., & Ng, S. M. (2023). Validation of the Chinese version stage of recovery instrument-30 (STORI-30) for adults with severe mental illness. BMC psychiatry, 23(1), 485.
• Mak, W. W. S., Chan, R. C. H., Wong, S. Y, S., Lau, J. T. F., Tang, W. K., Tang, A. K. L., et al. (2017). A cross-diagnostic investigation of the differential impact of discrimination on clinical and personal recovery. (2017). Psychiatric Services, 68, 159-166.
• Siu, B. W. M., Tsang, M. M. Y., Lee, V. C. K., Liu, A. C. Y., Tse, S., Luk, H. S. M., et al. (2016). Pathway to mental health recovery: A qualitative and quantitative study on the needs of Chinese psychiatric inpatients. BMC Psychiatry, 16, 236.
• Tsang, M. M. Y. (2014). From concept to practice: Recovery-oriented practice in psychiatric occupational therapy service in Hong Kong. World Federation of Occupational Therapists Bulletin, 70, 32-35.

Postnatal Mental Health Research

• Lyubenova, A., Neupane, D., Levis, B., Wu, Y., Sun, Y., He, C., Krishnan, A., Bhandari, P. M., Negeri, Z., Imran, M., Rice, D. B., Azar, M., Chiovitti, M. J., Saadat, N., Riehm, K. E., Boruff, J. T., Ioannidis, J. P. A., Cuijpers, P., Gilbody, S., Kloda, L. A., … Thombs, B. D. (2021). Depression prevalence based on the Edinburgh Postnatal Depression Scale compared to Structured Clinical Interview for DSM DIsorders classification: Systematic review and individual participant data meta-analysis. International journal of methods in psychiatric research, 30(1), e1860.
• Siu, B. W. M. (2015). Depression among post-natal women - ante-natal risk factors for post-natal depression in Chinese women. Hong Kong Journal of Mental Health, 41(2), 48-53.

Old-age Psychiatry Research

• Wong, M. M. C., Pang, P. F., Chan, C. F., Lau, M. S., Tse, W. Y., Lam, L. C. W., Lee, S. K. L., Tsoh, J., & Yan, C. T. Y. (2021). Wilson Sims Fall Risk Assessment Tool Versus Morse Fall Scale in Psychogeriatric Inpatients: a Multicentre Study. East Asian archives of psychiatry, 31(3), 67–70.
• Pan, I. M. Y., Lau, M. S., Mak, S. C., Hariman, K. W., Hon, S. K. H., Ching, W. K., Cheng, K. M., & Chan, C. F. (2020). Staging of Dementia Severity With the Hong Kong Version of the Montreal Cognitive Assessment (HK-MoCA)'s. Alzheimer disease and associated disorders, 34(4), 333–338.
• Chiu, H. F. K., Zhong, B. L., Leung, T., Li, S. W., Chow, P., Tsoh, J., et al. (2018). Development and validation of a new cognitive screening test: The Hong Kong Brief Cognitive Test (HKBC). International Journal of Geriatric Psychiatry, 33, 994-999.
• Wong, M. M. C., Chan, C. F., Li, S. W., & Lau, Y. M. (2015). Six-month follow-up of cognitive impairment and depressive symptoms in late-onset depression. East Asian Archives of Psychiatry, 25, 146-149.

Neuroimaging Research

• Cai, X. L., Pu, C. C., Zhou, S. Z., Wang, Y., Huang, J., Lui, S. S. Y., Møller, A., Cheung, E. F. C., Madsen, K. H., Xue, R., Yu, X., & Chan, R. C. K. (2023). Anterior cingulate glutamate levels associate with functional activation and connectivity during sensory integration in schizophrenia: a multimodal 1H-MRS and fMRI study. Psychological medicine, 53(11), 4904–4914.
• Wang, Y. M., Cai, X. L., Zhang, R. T., Zhang, Y. J., Zhou, H. Y., Wang, Y., Wang, Y., Huang, J., Wang, Y. Y., Cheung, E. F. C., & Chan, R. C. K. (2022). Altered brain structural and functional connectivity in schizotypy. Psychological medicine, 52(5), 834–843.
• Liang, Y. S., Zhou, S. Z., Zhang, Y. J., Cai, X. L., Wang, Y., Cheung, E. F. C., Lui, S. S. Y., Yu, X., Madsen, K. H., Ma, Y. T., & Chan, R. C. K. (2022). Altered empathy-related resting-state functional connectivity in patients with bipolar disorder. European archives of psychiatry and clinical neuroscience, 272(5), 839–848.
• Wang, Y. Y., Wang, Y., Huang, J., Sun, X. H., Wang, X. Z., Zhang, S. X., Zhu, G. H., Lui, S. S. Y., Cheung, E. F. C., Sun, H. W., & Chan, R. C. K. (2022). Shared and distinct reward neural mechanisms among patients with schizophrenia, major depressive disorder, and bipolar disorder: an effort-based functional imaging study. European archives of psychiatry and clinical neuroscience, 272(5), 859–871.
• Yang, Z. Y., Zhang, R. T., Wang, Y. M., Huang, J., Zhou, H. Y., Cheung, E. F. C., & Chan, R. C. K. (2021). Altered activation and functional connectivity in individuals with social anhedonia when envisioning positive future episodes. Psychological medicine, 1–9.
• Wang, Y. M., Zou, L. Q., Xie, W. L., Yang, Z. Y., Zhu, X. Z., Cheung, E. F. C., et al. (2018). Altered functional connectivity of the default mode network in patients with schizo-obsessive comorbidity: A comparison between schizophrenia and obsessive-compulsive disorder. Schizophrenia Bulletin.
• Wang, Y., Li, Z., Liu, W. H., Wei, X. H., Jiang, X. Q., Lui, S. S. Y., et al. (2018). Negative schizotypy and altered functional connectivity during facial emotion processing. Schizophrenia Bulletin, 44(2), 491-500.
• Deng, Y., Hung, K. S. Y., Lui, S. S. Y., Chui, W. W. H., Lee, J. C. W., Wang, Y., et al. (2019). Tractography-based classification in distinguishing patients with first-episode schizophrenia from healthy individuals. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 88, 66-73.
• Chiu, P. W., Lui, S. S. Y., Hung, K. S. Y., Chan, R. C. K., Chan, Q., Sham, P. C., et al. (2018). In vivo gamma-aminobutyric acid and glutamate levels in people with first-episode schizophrenia: A proton magnetic resonance spectroscopy study. Schizophrenia Research, 193, 295-303.
• Wang, Y., Liu, W. H., Li, Z., Wei, X. H., Jiang, X. Q., Geng, F. L., et al. (2016). Altered corticostriatal functional connectivity in individuals with high social anhedonia. Psychological Medicine, 46, 125-135.

Addiction Psychiatry

• Poon, J.Y.K., Hu, Hx., Lam, M., Lui, S. S. Y., & Chan, R. C. K. (2022). The Interplay Between Addictive Behaviour and Psychopathology and Personality in Substance Use Disorder: a Network Analysis in Treatment-Seeking Patients with Alcohol and Drug Use. Int J Ment Health Addiction .
• Chiu, C. W. C., Li, C. W. Y., Lai, E. S. K., Law, C. K. M., & Lam, M. (2023). Lifestyle redesign program with motivational enhancement for young people with drug use in Hong Kong: a retrospective study. Journal of Substance Use, 28(1), 123–129.
• Heung, J., Poon, J. Y. K., Tung, C. K., Yeung, A. S. W., & Lam, M. (2018). Confusion in sobriety: A case study on disulfiram encephalopathy in a middle-aged male patient. Alcohol and Alcoholism, 53, 497-498.
• Tung, C. K., Yeung, S. W., Chiang, T. P., Xu, K., & Lam, M. (2014). Reliability and validity of the Severity Dependence Scale in a Chinese sample of treatment-seeking ketamine users. East Asian Archives of Psychiatry, 24, 156-164.
• Tang, W., Lam, M., Leung, W., Sun, W., Chan, T., & Ungvari, G. S. (2013). Traditional Chinese Medicine diagnoses in persons with ketamine abuse. Journal of Traditional Chinese Medicine, 33, 164-169.

Mental Health Nursing

• Cho., Y. F. D., Leung., K. T., Ip, S. M. F., Ng, K. M., Yuen, W. S., Lai, K. Y. & Siu, L. W. W. (2021). A randomized controlled study to evaluate the effects of lifestyle intervention program for patients with severe mental illness taking second generation antipsychotics (SGAs) in body weight management and monitoring their body mass index (BMI). Archives of Nursing Research, 4(1), 1-10.
• Li, S. Y. H., & Bressington, D. (2019). The effects of mindfulness-based stress reduction on depression, anxiety, and stress in older adults: A systematic review and meta-analysis. International journal of mental health nursing, 28(3), 635–656.
• Lee, K. C., Tang, W. K., & Bressington, D. (2019). The experience of mindful yoga for older adults with depression. Journal of psychiatric and mental health nursing, 26(3-4), 87–100.
• Cheung, T., Mui, J., Ho, Y. S., & Chien, W. T. (2018). A scale for the management of aggressive and violent behaviour (C_MAVAS): Psychometric properties testing in mental health nurses. International Journal of Environmental Research and Public Health, 15, 1496.
• Bressington, D., Chien, W. T., Mui, J., Lam, K. K. C., Mahfoud, Z., White, J., et al. (2018). Chinese Health Improvement Profile for people with severe mental illness: A cluster-randomized, controlled trial. International Journal of Mental Health Nursing, 27, 841-855.
• Chien, W. T., Mui, J., Gray, R., & Cheung, E. (2016). Adherence therapy versus routine psychiatric care for people with schizophrenia spectrum disorders: A randomised controlled trial. BMC Psychiatry, 16, 42.
• Bressington, D., Mui, J., Wells, H., Chien, W. T., Lam, C., White, J. et al. (2016). Refocusing on physical health: Community psychiatric nurses' perceptions of using enhanced health checks for people with severe mental illness. International Journal of Mental Health Nursing, 25, 214-224.
• Bressington, D., Mui, J., Hulbert, S., Cheung, E., Bradford, B, & Gray, R. (2014). Enhanced physical health screening for people with severe mental illness in Hong Kong: Results from a one-year prospective case series study. BMC Psychiatry, 14, 57.

Cognitive Training and Psychotherapy Research

• Lo, P. M. T., Lui, S. S. Y., Law, C. K. M., Roberts, D. L., & Siu, A. M. H. (2023). A randomized controlled trial of social cognition and interaction training for persons with first episode psychosis in Hong Kong. Frontiers in psychiatry, 14, 1098662.
• So, H. W. S., Chan, H. K. G., Wong, K. W. C., Ching, W. K. E., Lee, S. W. S., Wong, C. W. B., Zhu, C., Sun, X., Chung, K. H. L., Hung, A. Y., Wong, O. Y. J., & Chan, S. M. S. S. (2021). A randomised controlled trial of metacognitive training for psychosis, depression, and belief flexibility. Journal of affective disorders, 279, 388–397.
• Lo, H. H., Ho, W. C., Lau, E. N., Lo, C. W., Mak, W. W. S., Ng, S. M., Wong, S. Y., Wong, J. O., Lui, S. S. Y., Lo, C. S., Lin, E. C., Poon, M. F., Choi, K., & Leung, C. W. (2019). A Brief Mindfulness-Based Family Psychoeducation Intervention for Chinese Young Adults With First Episode Psychosis: A Study Protocol. Frontiers in psychology, 10, 516.
• Lo, C. S. L., Ho, S. M. Y., Yu, N. K. K., & Siu, B. P. Y. (2014). Decentering mediates the effect of ruminative and experiential self-focus on negative thinking in depression. Cognitive Therapy and Research, 38, 389-396.
• Tsang, M. M. Y., & Man, D. W. K. (2013). A virtual reality-based vocational training system (VRVTS) for people with schizophrenia in vocational rehabilitation. Schizophrenia Research, 144, 51-62.

Child Psychiatry

• Chung, S. T., Lok, E. Y. C., Chan, Q. K. N., Cheng, K. M., Lam, S. M., & Lui, S. S. Y. (2023). Psychometric Properties of the Caregiver Strain Questionnaire in a Chinese Sample of Caregivers of Children with Autism Spectrum Disorder. Journal of autism and developmental disorders, 10.1007/s10803-023-06028-0.
• Zhou, H., Cui, X., Yang, B., Shi, L., Luo, X., Cheung, E. F. C., Lui, S. S. Y., & Chan, R. C. K. (2022). Audiovisual Temporal Processing in Children and Adolescents With Schizophrenia and Children and Adolescents With Autism: Evidence From Simultaneity-Judgment Tasks and Eye-Tracking Data. Clinical Psychological Science, 10(3), 482-498.
• Lai, E. C. L., Lau, Z., Lui, S. S. Y., Lok, E., Tam, V., Chan, Q., et al. (2017). Meta-analysis of neuropsychological measures of executive functioning in children and adolescents with high-functioning autism spectrum disorder. Autism Research, 10, 911-939.
• Yang, T. X., Xie, W. Z., Chen, C. S., Altgassen, M., Wang, Y., Cheung, E. F. C., et al. (2017). The development of multitasking in children aged 7-12 years: Evidence from cross-sectional and longitudinal data. Journal of Experimental Child Psychology, 161, 63-80.

Forensic Psychiatry

• Lam, E. H. Y., Lai, E. S. K., Lai, E. C. L., Lau, E., Siu, B. W. M., Tang, D. Y. Y., Mok, C. C. M., & Lam, M. (2023). Effect of Community Treatment Orders on Mental Health Service Usage, Emergency Visits, and Violence: a Systematic Review and Meta-Analysis. East Asian archives of psychiatry, 33(2), 37–43.
• Siu, B. W. M., So, J. W. L., Yuen, K. K., Chan, A. W. L., Chan, C., Lai, E. S. K., Leung, H. W., & Lam, M. (2020). A retrospective study on risk assessment and management of forensic psychiatric inpatients in Hong Kong. Behavioral sciences & the law, 38(5), 493–505.
• Siu, B. W., Chan, O., Au-Yeung, C. C., Chow, K. K., Liu, A. C., Tang, D. Y., Lui, S. H., Cheung, E. F., & Lam, M. (2018). Profiling Mentally Ill Offenders in Hong Kong: a 5-year Retrospective Review Study. East Asian archives of psychiatry, 28(4), 114–121.
• Siu, B. W. M., Au Yeung, C. C. Y., Chan, A. W. L., Chan, L. S. Y., Yuen, K. K., Leung, H. W., et al. (2017). Validation of the "Security Needs Assessment Profile" for measuring the profiles of security needs of Chinese forensic psychiatric inpatients. International Journal of Law and Psychiatry, 54, 61-66.
• Tang, D. Y. Y., Liu, A. C. Y., Lui, S. S. Y., Lam, B. Y. H., Siu, B. W. M., Lee, T. M. C., et al. (2016). Facial emotion perception impairments in schizophrenia patients with comorbid antisocial personality disorder. Psychiatry Research, 236, 22-27.