The Research Subcommittee aims to promote scientific research and evidence-based practice in mental health. The Subcommittee actively provides supervision to research projects in Castle Peak Hospital (CPH), manages the research information centre, supports community mental health research projects, and develops a network with world-renowned research institutes. It also provides professional support to CPH researchers, and shares research output through a centralised research database.

As at July 2022 , CPH has cumulated a research output of 624 research reports / manuscripts / published articles and 544 conference presentations.

Highlights of accomplishments

• Organises regular workshops. These workshops are conducted by experienced researchers, aiming at promoting evidence-based practice in mental health, enhancing participants’ knowledge and improving their skills in carrying out a research.
• Develops the database of research conducted / conducting by colleagues of psychiatric service of New Territories West Cluster (NTWC) and uploads the database to the intranet of CPH
• Coordinates the SPSS web-base access stations in CPH
• Sets up the “Research Information Centre” at Block S, CPH
• Sets up the “Research Collection Corner” in the CPH Library
• Acts as a “clearing house” to assist Hospital Chief Executive to scrutinise the applications of all clinical and drug trials in the psychiatric units of NTWC, and standardise the application and implementation procedures
• Assists designing questionnaires inquiring the provisions of community residential care for psychiatric patients

Clinical Psychiatry Research

• Xie, D. J., Shi, H. S., Lui, S. S. Y., Shi, C., Li, Y., Ho, K. K. Y., et al. (2018). Cross Cultural validation and extension of the Clinical Assessment Interview for Negative Symptoms (CAINS) in the Chinese context: Evidence from a spectrum perspective. Schizophrenia Bulletin, 44(2), 547-555.
• Hui, C. L. M., Honer, W. G., Lee, E. H. M., Chang, W. C., Chan, S. K. W., Chen, E. S. M., et al. (2018). Long-term effects of discontinuation from antipsychotic maintenance following first-episode schizophrenia and related disorders: A 10 year follow-up of a randomised, double-blind trial. The Lancet Psychiatry, 5, 432-442.
• Cheng, K. M., Siu, B. W. M., Au Yeung, C. C. Y., Chiang, T. P., So, M. H., & Yeung, M. C. W. (2018). Telepsychiatry for stable Chinese psychiatric out-patients in custody in Hong Kong: A case-control pilot study. Hong Kong Medical Journal, 24, 378-383.
• Wong, S. Y., Zhang, D. X., Li, C. C. K., Yip, B. H. K., Chan, D. C. C., Ling, Y. M., et al. (2017). Comparing the effects of mindfulness-based cognitive therapy and sleep psycho-education with exercise on chronic insomnia: A randomised controlled trial. Psychotherapy and Psychosomatics, 86, 241-253.
• Chang, W. C., Wong, C. S. M., Chen, E. Y. H., Lam, L. C. W., Chan, W. C., Ng, R. M. K., et al. (2017). Lifetime prevalence and correlates of schizophrenia-spectrum, affective and other non-affective psychotic disorders in the Chinese adult population. Schizophrenia Bulletin, 43, 1280-1290.

Endophenotype research

• Lui, S. S. Y., Hung, K. S. Y., Wang, Y., Ho, K. K. Y., Yeung, H. K. H., Wang, Y., et al. (2018). Clustering of schizotypal features in unaffected first-degree relatives of schizophrenia patients. Schizophrenia Bulletin, 44(2), 536-546.
• Tin, L. N. W., Lui, S. S. Y., Ho, K. K. Y., Hung, K. S. Y., Wang, Y., Yeung, H. K. H., et al. (2018). High-functioning autism patients share similar but more severe impairments in verbal theory of mind than schizophrenia. Psychological Medicine, 48, 1264-1273.
• Chan, R. C. K., Xie, W., Geng, F. L., Wang, Y., Lui, S. S. Y., Wang, C. Y., Yu, X., et al. (2016). Clinical utility and lifespan profiling of neurological soft signs in schizophrenia spectrum disorders. Schizophrenia Bulletin, 42, 560-570.
• Lui, S. S. Y., Liu, A. C. Y., Chui, W. W. H., Li, Z., Geng, F., Wang, Y., et al. (2016). The nature of anhedonia and avolition in patients with first-episode schizophrenia. Psychological Medicine, 46, 437-447.
• Chan, R. C. K., Lui, S. S. Y., Wang, Y., Liu, A. C. Y., Chui, W. W. H., Shum, D. H. K., et al. (2013). Patients with bipolar disorders share similar but attenuated prospective memory impairments with patients with schizophrenia. Psychological Medicine, 43, 1639-1649.

Genetics Research

• Loh, P. R., Bhatia, G., Gusev, A., Finucane, H. K., Bulik-Sullivan, B. K., Pollack, S. J., et al. (2015). Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis. Nature Genetics, 47, 1385-1392.
• Schizophrenia Working Group of the Psychiatric Genomics Consortium. (2014). Biological insights from 108 schizophrenia-associated genetic loci. Nature, 511, 421-427.
• Wong, E. H. M., So, H. C., Li, M., Wang, Q., Butler, A. W., Paul, B., et al. (2014). Common variants on Xq28 conferring risk of schizophrenia in Han Chinese. Schizophrenia Bulletin, 40, 777-786.

Recovery-related Research

• Mak, W. W. S., Chan, R. C. H., Wong, S. Y, S., Lau, J. T. F., Tang, W. K., Tang, A. K. L., et al. (2017). A cross-diagnostic investigation of the differential impact of discrimination on clinical and personal recovery. (2017). Psychiatric Services, 68, 159-166.
• Siu, B. W. M., Tsang, M. M. Y., Lee, V. C. K., Liu, A. C. Y., Tse, S., Luk, H. S. M., et al. (2016). Pathway to mental health recovery: A qualitative and quantitative study on the needs of Chinese psychiatric inpatients. BMC Psychiatry, 16, 236.
• Tsang, M. M. Y. (2014). From concept to practice: Recovery-oriented practice in psychiatric occupational therapy service in Hong Kong. World Federation of Occupational Therapists Bulletin, 70, 32-35.

Postnatal Mental Health Research

• Siu, B. W. M. (2015). Depression among post-natal women - ante-natal risk factors for post-natal depression in Chinese women. Hong Kong Journal of Mental Health, 41(2), 48-53.

Old-age Psychiatry Research

• Chiu, H. F. K., Zhong, B. L., Leung, T., Li, S. W., Chow, P., Tsoh, J., et al. (2018). Development and validation of a new cognitive screening test: The Hong Kong Brief Cognitive Test (HKBC). International Journal of Geriatric Psychiatry, 33, 994-999.
• Wong, M. M. C., Chan, C. F., Li, S. W., & Lau, Y. M. (2015). Six-month follow-up of cognitive impairment and depressive symptoms in late-onset depression. East Asian Archives of Psychiatry, 25, 146-149.

Neuroimaging Research

• Wang, Y. M., Zou, L. Q., Xie, W. L., Yang, Z. Y., Zhu, X. Z., Cheung, E. F. C., et al. (2018). Altered functional connectivity of the default mode network in patients with schizo-obsessive comorbidity: A comparison between schizophrenia and obsessive-compulsive disorder. Schizophrenia Bulletin.
• Wang, Y., Li, Z., Liu, W. H., Wei, X. H., Jiang, X. Q., Lui, S. S. Y., et al. (2018). Negative schizotypy and altered functional connectivity during facial emotion processing. Schizophrenia Bulletin, 44(2), 491-500.
• Deng, Y., Hung, K. S. Y., Lui, S. S. Y., Chui, W. W. H., Lee, J. C. W., Wang, Y., et al. (2019). Tractography-based classification in distinguishing patients with first-episode schizophrenia from healthy individuals. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 88, 66-73.
• Chiu, P. W., Lui, S. S. Y., Hung, K. S. Y., Chan, R. C. K., Chan, Q., Sham, P. C., et al. (2018). In vivo gamma-aminobutyric acid and glutamate levels in people with first-episode schizophrenia: A proton magnetic resonance spectroscopy study. Schizophrenia Research, 193, 295-303.
• Wang, Y., Liu, W. H., Li, Z., Wei, X. H., Jiang, X. Q., Geng, F. L., et al. (2016). Altered corticostriatal functional connectivity in individuals with high social anhedonia. Psychological Medicine, 46, 125-135.

Addiction Psychiatry

• Heung, J., Poon, J. Y. K., Tung, C. K., Yeung, A. S. W., & Lam, M. (2018). Confusion in sobriety: A case study on disulfiram encephalopathy in a middle-aged male patient. Alcohol and Alcoholism, 53, 497-498.
• Tung, C. K., Yeung, S. W., Chiang, T. P., Xu, K., & Lam, M. (2014). Reliability and validity of the Severity Dependence Scale in a Chinese sample of treatment-seeking ketamine users. East Asian Archives of Psychiatry, 24, 156-164.
• Tang, W., Lam, M., Leung, W., Sun, W., Chan, T., & Ungvari, G. S. (2013). Traditional Chinese Medicine diagnoses in persons with ketamine abuse. Journal of Traditional Chinese Medicine, 33, 164-169.

Mental Health Nursing

• Cheung, T., Mui, J., Ho, Y. S., & Chien, W. T. (2018). A scale for the management of aggressive and violent behaviour (C_MAVAS): Psychometric properties testing in mental health nurses. International Journal of Environmental Research and Public Health, 15, 1496.
• Bressington, D., Chien, W. T., Mui, J., Lam, K. K. C., Mahfoud, Z., White, J., et al. (2018). Chinese Health Improvement Profile for people with severe mental illness: A cluster-randomized, controlled trial. International Journal of Mental Health Nursing, 27, 841-855.
• Chien, W. T., Mui, J., Gray, R., & Cheung, E. (2016). Adherence therapy versus routine psychiatric care for people with schizophrenia spectrum disorders: A randomised controlled trial. BMC Psychiatry, 16, 42.
• Bressington, D., Mui, J., Wells, H., Chien, W. T., Lam, C., White, J. et al. (2016). Refocusing on physical health: Community psychiatric nurses' perceptions of using enhanced health checks for people with severe mental illness. International Journal of Mental Health Nursing, 25, 214-224.
• Bressington, D., Mui, J., Hulbert, S., Cheung, E., Bradford, B, & Gray, R. (2014). Enhanced physical health screening for people with severe mental illness in Hong Kong: Results from a one-year prospective case series study. BMC Psychiatry, 14, 57.

Cognitive Training and Psychotherapy Research

• Lo, C. S. L., Ho, S. M. Y., Yu, N. K. K., & Siu, B. P. Y. (2014). Decentering mediates the effect of ruminative and experiential self-focus on negative thinking in depression. Cognitive Therapy and Research, 38, 389-396.
• Tsang, M. M. Y., & Man, D. W. K. (2013). A virtual reality-based vocational training system (VRVTS) for people with schizophrenia in vocational rehabilitation. Schizophrenia Research, 144, 51-62.

Child Psychiatry

• Lai, E. C. L., Lau, Z., Lui, S. S. Y., Lok, E., Tam, V., Chan, Q., et al. (2017). Meta-analysis of neuropsychological measures of executive functioning in children and adolescents with high-functioning autism spectrum disorder. Autism Research, 10, 911-939.
• Yang, T. X., Xie, W. Z., Chen, C. S., Altgassen, M., Wang, Y., Cheung, E. F. C., et al. (2017). The development of multitasking in children aged 7-12 years: Evidence from cross-sectional and longitudinal data. Journal of Experimental Child Psychology, 161, 63-80.

Forensic Psychiatry

• Siu, B. W. M., Au Yeung, C. C. Y., Chan, A. W. L., Chan, L. S. Y., Yuen, K. K., Leung, H. W., et al. (2017). Validation of the "Security Needs Assessment Profile" for measuring the profiles of security needs of Chinese forensic psychiatric inpatients. International Journal of Law and Psychiatry, 54, 61-66.
• Tang, D. Y. Y., Liu, A. C. Y., Lui, S. S. Y., Lam, B. Y. H., Siu, B. W. M., Lee, T. M. C., et al. (2016). Facial emotion perception impairments in schizophrenia patients with comorbid antisocial personality disorder. Psychiatry Research, 236, 22-27.
• Chan, O., & Chow, K. K. W. (2014). Assessment and determinants of aggression in a forensic psychiatric institution in Hong Kong, China. Psychiatry Research, 220, 623-630.